Solution and solid-state < sup > 33 < /sup > S NMR studies of < sup > 33 < /sup > S-labeled taurine

Magn Reson Chem. 2023 Aug 23. doi: 10.1002/mrc.5387. Online ahead of print.ABSTRACTSulfur-33(33 S) stable-isotope labeled taurine, 2-aminoethanesulfonic acid, has been synthesized, and a series of solution and solid-state 33 S nuclear magnetic resonance (NMR) experiments at 14.1 and 18.8 T, respectively, have been carried out at room temperature. The single peak of a solution 33 S NMR spectrum in 0.1-mM [33 S]-taurine in D2 O can be observed with the signal-to-noise (S/N) ratio of 9 in 40,000 scans, which paves the way toward in vivo analysis of pharmacokinetics and metabolism of 33 S-labeled taurine. Undistorted magic-angle-spinning (MAS) and static 33 S NMR spectra of polycrystalline [33 S]-taurine are observed with sufficient S/N ratios for analysis, and the magnitudes of 33 S EFG and CS tensors can be obtained.PMID:37612854 | DOI:10.1002/mrc.5387

Source: Magnetic Resonance in Chemistry : MRC - August 24, 2023 Category: Chemistry Authors: Yuichi Masuda Shinobu Ohki Yuuki Mogami Kenzo Deguchi Kenjiro Hashi Atsushi Goto Tadashi Shimizu Kazuhiko Yamada Source Type: research