Persistent modulatory actions and task switching in the feeding network of Aplysia

Curr Opin Neurobiol. 2023 Aug 23;82:102775. doi: 10.1016/j.conb.2023.102775. Online ahead of print.ABSTRACTThe activity of multifunctional networks is configured by neuromodulators that exert persistent effects. This raises a question, does this impact the ability of a network to switch from one type of activity to another? We review studies that have addressed this question in the Aplysia feeding circuit. Task switching in this system occurs "asymmetrically." When there is a switch from egestion to ingestion neuromodulation impedes switching (creates a "negative bias"). When there is a switch from ingestion to egestion the biasing is "positive." Ingestion promotes subsequent egestion. We contrast mechanisms responsible for the two types of biasing and show that the observed asymmetry is a consequence of the fact that there is more than one set of egestive circuit parameters.PMID:37625344 | DOI:10.1016/j.conb.2023.102775

Source: Current Opinion in Neurobiology - August 25, 2023 Category: Neurology Authors: Elizabeth C Cropper Matthew Perkins Jian Jing Source Type: research