Maturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32  Weeks of Gestation

ConclusionBirthweight and PNA are the most important predictors for maturational changes in paracetamol clearance and its glucuronidation, sulfation and oxidation. As a result, dosing based on bodyweight alone will not lead to consistent paracetamol concentrations among preterm neonates.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research