Low-Intensity Focused Ultrasound Targeting the Bilateral Nucleus Accumbens as a Potential Treatment for Substance Use Disorder: A First-in-Human Report

Over 110,000 drug overdose deaths occurred in the U.S. in 2022, the most in recorded history, with>75% involving opioids (1). Moreover, there are 46.3 million people in the United States with a substance use disorder (SUD), with only ∼7% receiving specialty treatment (2). There have been significant efforts to improve treatment outcomes; for example, the combination of behavioral treatment with medication for opioid use disorder (MOUD) has been associated with increased treatment retention and reduced opioid craving and use (3 ,4).

Source: Biological Psychiatry - August 22, 2023 Category: Psychiatry Authors: James J. Mahoney, Daisy G.Y. Thompson-Lake, Manish Ranjan, Jennifer L. Marton, Jeffrey S. Carpenter, Wanhong Zheng, James H. Berry, Daniel L. Farmer, Pierre D ’Haese, Victor S. Finomore, Padma Tirumalai, Ashley S. Mears, Jacob Suffridge, Ashley Ames, Sa Tags: Correspondence Source Type: research