Research news in clinical context

Cervical screening intervals can be extended in women living with HIV following an initial negative human papillomavirus DNA test Firmer evidence is needed to guide cervical cancer screening in women with HIV. A study from India enrolled women with no history of cervical intraepithelial neoplasia (CIN) or cancer and with normal colposcopy at baseline. Participants underwent annual colposcopies followed by three yearly human papillomavirus (HPV) DNA testing. Among 869 women observed over a median of 3.5 years (IQR 2.8–4.3), 54 had incident CIN (CIN 1=35, CIN 2+=19). Among women with CIN endpoint assessments, CIN incidence was lower in women with a negative baseline HPV test (20 of 575, 3.5%) compared with those with baseline HPV detection (30 of 148, 20.3%). Most women who tested HPV negative at baseline remained HPV negative during follow-up. CIN incidence was lower among persistently HPV-negative women (14 of 499, 2.8%) compared with women with...
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Perspectives Source Type: research