Seasonal Variation of Laboratory Animals as a Consideration for Research Reproducibility

Comp Med. 2023 Aug 7. doi: 10.30802/AALAS-CM-23-000033. Online ahead of print.ABSTRACTLaboratory rodents are generally maintained under standardized conditions in order to control the effects of extrinsic factorson research. However, despite attempts to standardize conditions, variability can nonetheless confound efforts directed towardresearch reproducibility. Here we explore some of the existing literature on the potential impact of seasonal variability as anextrinsic factor that can potentially impact research results. We discuss the influence of seasonal changes in association withan internal clock mechanism that might account for such variation, noting that the mechanisms and interactions of seasonal and internal time-keeping remain largely undetermined. Finally, we speculate that seasonal changes experienced by personnel who handle animals may influence the animals in ways that result in physiologic and behavioral changes.PMID:37550067 | DOI:10.30802/AALAS-CM-23-000033
Source: Comparative Medicine - Category: Zoology Authors: Source Type: research