Continuous home cage monitoring of activity and sleep in mice during repeated paroxetine treatment and discontinuation

ConclusionsThis study provides the first example of how continuous non-invasive home cage monitoring can be used to detect objective behavioural changes in activity and sleep during and after drug treatment in mice. These data suggest that effects of paroxetine administration reversed soon after its discontinuation but identified an emergent change in sleep bout duration, which could be used as a biomarker in future preclinical studies to prevent or minimise SSRI discontinuation symptoms.
Source: Psychopharmacology - Category: Psychiatry Source Type: research