Isolation and characterization of three novel Acinetobacter baumannii phages from Beninese hospital wastewater

AbstractAcinetobacter baumannii is an opportunistic pathogen that is mostly associated with hospital-acquired infections. The rapid emergence of multi- and pan-drug-resistantAcinetobacter strains poses an increasing challenge in hospitals. Phage therapy offers one treatment option for infections caused byA. baumannii. We isolated three phages from Beninese hospital wastewater – fBenAci001, fBenAci002, and fBenAci003 – that infected clinicalA. baumannii strains from Finnish patients. Phylogenetic analysis showed that these phages resemble phages of the genusFriunavirus, familyAutographiviridae. The isolated phages meet the requirements set for phages used for phage therapy. However, they were found to have a narrow host range, which may limit their therapeutic use.
Source: Archives of Virology - Category: Virology Source Type: research