Effect of intra-arterial thrombolysis following successful endovascular thrombectomy on functional outcomes in patients with large vessel occlusion acute ischemic stroke: A post-CHOICE meta-analysis

Endovascular thrombectomy (EVT) is the standard treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Although> 70% of patients in the trials assessing EVT for AIS-LVO had successful recanalization, only a third ultimately achieved favorable outcomes. A “no-reflow” phenomenon due to distal microcirculation disruption might contribute to such suboptimal outcomes. Combining intra-arterial (IA) tissue plasminogen activator (tPA) and EVT to reduce the distal microthrombi burden was investigated in a few studies.

Source: Journal of Stroke and Cerebrovascular Diseases - May 20, 2023 Category: Neurology Authors: Mohamed Elfil, Sherief Ghozy, Ahmed Elmashad, Hazem S Ghaith, Mohammad Aladawi, Alis J. Dicpinigaitis, Ossama Yassin Mansour, Priyank Khandelwal, Kaiz Asif, May Nour, Gabor Toth, Fawaz Al-Mufti Source Type: research