Impact of Dexmedetomidine Infusion on Opioid and Benzodiazepine Doses in Ventilated Pediatric Patients in the Cardiac Intensive Care Unit

CONCLUSION: While in patients ventilated < 5 days opioids initially increased and then quickly decreased in the 72 h following DEX initiation, among patients ventilated ≥ 5 days opioids doubled, then decreased only minimally; benzodiazepines decreased minimally in both groups, although more slowly in the long-ventilation cohort. These findings may inform decision-making on timing of DEX initiation in ventilated patients already being treated with opioid or benzodiazepine infusions.PMID:37550522 | DOI:10.1007/s40272-023-00587-6

Source: Paediatric Drugs - August 7, 2023 Category: Pediatrics Authors: Reuth Nir Francesca Sperotto Manasee Godsay Minmin Lu John N Kheir Source Type: research