Inhibition of PI3K p110 δ activity reduces IgE production in IL-4 and anti-CD40 stimulated human B cell cultures

In conclusion, PI3K p110δ signalling is required for the production of human IgE, which makes it a pharmacological target for the treatment of allergic disease.PMID:37530226 | DOI:10.1111/imm.13684

Source: Immunology - August 2, 2023 Category: Allergy & Immunology Authors: Anna Cutrina-Pons Aloka De Sa David J Fear Hannah J Gould Faruk Ramadani Source Type: research