Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings.

Conditioning of Rag1 mutant hypomorphic mice with CD45-ADC allowed full donor chimerism and robust immune reconstitution after congenic and haploidentical HCT, without graft-versus-host disease, opening the perspective of similar approaches in patients.

Source: Journal of Allergy and Clinical Immunology - August 8, 2023 Category: Allergy & Immunology Authors: Francesca Pala, Cristina Corsino, Enrica Calzoni, Anna Villa, Stefania Pittaluga, Rahul Palchaudhuri, Marita Bosticardo, Luigi D. Notarangelo Source Type: research