Lymph node sharing between pancreas, gut, and liver leads to immune crosstalk and regulation of pancreatic autoimmunity

Lymph nodes (LNs) are critical for surveilling the tissue they drain. How LNs integrate and respond to complex cues in the situation of LN sharing between organs is unknown. Brown and Komnick et  al. discover that LN co-drainage between the pancreas, gut, and liver leads to immune crosstalk, impacting pancreatic autoimmunity.

Source: Immunity - August 8, 2023 Category: Allergy & Immunology Authors: Hailey Brown, Macy R. Komnick, Pamela H. Brigleb, Terence S. Dermody, Daria Esterh ázy Tags: Article Source Type: research