Effect of Material Properties and Variability of Mannitol on Tablet Formulation Development

ConclusionThe study elucidated the linkage between fundamental material attributes and mechanical properties of mannitol, highlighting their impact on tablet defects and compaction performance in compression. A comprehensive understanding of the variability in mannitol properties between vendors and lots is crucial for successful formulation development, particularly when high percentages of mannitol are included as a brittle excipient.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research