A feedback loop between lncRNA MALAT1 and DNMT1 promotes triple-negative breast cancer stemness and tumorigenesis

CONCLUSION: MALAT1 downregulated DNMT1 by miR-137/BCL11A pathway to enhance TNBC stemness and tumorigenesis; meanwhile, DNMT1/MALAT1 formed a positive feedback loop to continuously promote TNBC malignant behaviors.PMID:37548553 | DOI:10.1080/15384047.2023.2235768

Source: Cancer Biology and Therapy - August 7, 2023 Category: Cancer & Oncology Authors: Yu Hu Yuqiong He Na Luo Xin Li Lei Guo Kejing Zhang Source Type: research