Insulin Resistance Is an Alternative, Novel Risk Factor for Diabetes-Associated Periodontitis

AbstractPurpose of ReviewPeriodontitis is one of the diabetic complications and is exacerbated under diabetes. Epidemiological and basic studies suggested that the progression of periodontitis might associate with insulin resistance. This review aims to discuss the molecular mechanism of insulin resistance in the pathogenesis of diabetes-related periodontitis.Recent FindingsObese model rodents showed insulin resistance in the gingiva and exacerbated experimental periodontitis. Studies using conditional insulin receptor knockout mice have demonstrated that insulin resistance in the periodontal tissue-consisting cells such as gingival fibroblasts and vascular endothelial cells may contribute to the exacerbation of periodontitis. Insulin resistance might disrupt these regulations in periodontal tissue, resulting in the exacerbation of periodontitis.SummaryLoss of insulin action and insulin resistance in peripheral tissue could be novel pathogenic factor in diabetes-related periodontitis. Improving insulin sensitivity could be a future therapeutic strategy to cure and care for periodontitis in people with insulin resistance and obesity/diabetes.
Source: Current Oral Health Reports - Category: Dentistry Source Type: research