Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency

CONCLUSION: These results point to a critical role for claudin-12 in maintaining the myelin barrier presumably via Pmp22 and highlight restoration of the hedgehog pathway as a potential treatment strategy for painful inflammatory neuropathy.PMID:37527762 | DOI:10.1016/j.nbd.2023.106246

Source: Neurobiology of Disease - August 1, 2023 Category: Neurology Authors: Jeremy Tsung-Chieh Chen Xiawei Hu Isabel U C Otto Christina Sch ürger Bruno Rogalla von Bieberstein Kathrin Doppler Susanne M Krug Mohammed K Hankir Rosel Blasig Claudia Sommer Alexander Brack Ingolf E Blasig Heike L Rittner Source Type: research