Acetylglutamine Differentially Associated with First-Time Versus Recurrent Stroke

The objective of this study was to identify metabolite risk markers that are associated with recurrent stroke. We performed targeted metabolomic profiling of 162 metabolites by liquid chromatography-tandem mass spectrometry in baseline plasma in a stroke case-cohort study nested within the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, an observational cohort study of 30,239 individuals aged 45 and older enrolled in 2003 –2007. Weighted Cox proportional hazard models were used to identify metabolites that had a differential effect on first-time versus recurrent stroke using an interaction term between metabolite and prior stroke at baseline (yes or no). The study included 1391 incident stroke cases identified duri ng 7.1 ± 4.5 years of follow-up and 1050 participants in the random cohort sample. Among 162 metabolites, 13 candidates had a metabolite-by-prior stroke interaction at ap-value<0.05, with one metabolite, acetylglutamine, surpassing the Bonferroni adjustedp-value threshold (p for interaction = 5.78 × 10−5). In an adjusted model that included traditional stroke risk factors, acetylglutamine was associated with recurrent stroke (HR = 2.27 per SD increment, 95% CI = 1.60 –3.20,p = 3.52 × 10−6) but not with first-time stroke (HR = 0.96 per SD increment, 95% CI = 0.87 –1.06,p = 0.44). Acetylglutamine was associated with recurrent stroke but not first-time stroke, independent of traditional stroke risk factors. Future studies are w...

Source: Translational Stroke Research - August 2, 2023 Category: Neurology Source Type: research