Effects of ruxolitinib on murine regulatory T cells are immune-context dependent
Aplastic anemia (AA) is a bone marrow failure (BMF) disorder mediated by immune dysfunction resulting in pancytopenia and marrow hypoplasia. To study immune AA experimentally, BMF can be induced in mice with major histocompatibility complex-mismatched lymph node (LN) cell infusion after sublethal total body irradiation (TBI). Based on the suppressive effect of the JAK 1/2 inhibitor ruxolitinib (RUX) on T-cell activation and inflammatory cytokine production, we previously studied RUX in our murine BMF model.
Source: Experimental Hematology - Category: Hematology Authors: Nidhi Aggarwal, Ash Lee Manley, Jichun Chen, Emma M. Groarke, Xingmin Feng, Neal S. Young Tags: Brief Communication Source Type: research