Whole-Exome sequencing identifies GYS2 biallelic variants in individuals with suspected epilepsy

The principal source of energy for mammalian brains is glucose [1]. Neurons are among the cells that consume the most energy and rely on a steady supply of glucose [2]. Despite accounting for only 2% of total body weight, the human brain consumes 20% of all glucose-derived energy, making it the leading glucose consumer [3]. Glucose metabolism is indirectly involved in ATP generation which provides energy that is essential for fundamental neuronal processes [4]. Furthermore, glucose metabolism produces energy (ATP) and precursor material for neurotransmittersynthesis [5].

Source: Seizure: European Journal of Epilepsy - July 26, 2023 Category: Neurology Authors: Muhammad Ilyas, Dorothea Holzwart, Rafaqat Ishaq, Yasir Ali, Umme Habiba, Asad Mehmood Raja, Sadia Saeed, Uzma Abdullah, Sadiq Noor Khan, Ata Ullah, Ghazala Kaukab Raja, Shahid Mehmood Baig, Walid Fazeli, Wolfram S. Kunz, Pakeeza Arzoo Shaiq Source Type: research