Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome

Respiratory distress syndrome (RDS) in premature infants is caused by insufficient amounts of endogenous lung surfactant and is efficiently treated with replacement therapy using animal-derived surfactant preparations. On the other hand, adult/acute RDS (ARDS) occurs secondary to e.g., sepsis, aspiration of gastric contents, and multitrauma and is caused by alveolar endothelial damage, leakage of plasma components into the airspaces and inhibition of surfactant activity. Instillation of surfactant preparations in ARDS has so far resulted in very limited treatment effects, partly due to inactivation of the delivered surfactants in the airspace.

Source: Translational Research - July 25, 2023 Category: Research Authors: Pavol Mikolka, Nina Kronqvist, Marie Haegerstrand-Bj örkman, Kristaps Jaudzems, Petra Kosutova, Maros Kolomaznik, Mihkel Saluri, Michael Landreh, Andrea Calkovska, Tore Curstedt, Jan Johansson Source Type: research