NR4A1 destabilizes < i > TNF < /i > mRNA in microglia and modulates stroke outcomes

by Yao Yao Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia. Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. This Primer explores a PLOS Biology study that identifies a new mechanism through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002226

Source: PLoS Biology: Archived Table of Contents - July 25, 2023 Category: Biology Authors: Yao Yao Source Type: research

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