Genome-wide association study identifies novel risk loci for apical periodontitis

Apical periodontitis (AP) is a common consequence of root canal infection leading to periapical bone resorption. Microbial and host genetic factors, and their interactions, have been shown to play a role in AP development and progression. Variations in a few genes have been reported in association with AP, however, the lack of genome-wide studies has hindered progress in understanding the mechanisms involved in AP. Here, we report the first genome-wide association study of AP in a large and well-characterized population.

Source: Journal of Endodontics - July 25, 2023 Category: Dentistry Authors: L.E. Petty, R. Silva, L. Chaves de Souza, A.R. Vieira, D.M. Shaw, J.E. Below, A. Letra Tags: Clinical Research Source Type: research