An extremely rare case of pulmonary epithelioid hemangioendothelioma

Histological features of EHE: Hematoxylin and eosin (H&E) indicated that the tumor tissue morphology is diverse, showing nodular growth, showing well-defined eosinophilic nodules, and transparent degeneration or coagulative necrosis similar to amyloidosis or chondroma can be seen in the center. There are many cells around the nodule, and the cell mass located in the mucilaginous chondroid matrix extends into the alveolar cavity, bronchioles, blood vessels, and lymphatic vessel. Part of the alveoli are filled with patches of tumor cells, presenting as papillary or glomerular like hyperplasia, with obvious hyaline degeneration in the interstitium, and relatively normal alveolar septa. Tumor cells have prominent epithelioid features, similar to epithelial cells, tissue cells, or decidual cells, arranged in a nest, cord, or irregular shape. CK7 and TFE-3 staining was negative. CAMTA-1, CD34, and CD31 were also positive. (a: CK7, b: TFE-3, c: CAMTA-1, d: CD34, e: CD31, f: Hematoxylin and eosin). AbstractEpithelioid emangioendothelioma (EHE) is a rare tumor originating from vascular endothelial cells, which belongs to malignant vascular tumors with low to moderate differentiation and potential metastatic ability and its incidence rate is less than one in a million. We herein report a rare case of EHE of pulmonary origin and a review of the literature concerning the clinical and pathological features of this disease. The patient underwent left upper lobectomy to completely extirpate...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research