Evaluating Pareto optimal tradeoffs for hippocampal avoidance whole brain radiotherapy with knowledge-based multicriteria optimization

The goal of this study is to investigate the Pareto optimal tradeoffs between target coverage and hippocampal sparing using knowledge-based multicriteria optimization (MCO). Ten prior clinical cases were selected that were treated with hippocampal avoidance whole brain radiotherapy (HA-WBRT) using VMAT. A new, balanced plan was generated for each case using an in-house RapidPlan model in the Eclipse V16.1 treatment planning system. The MCO decision support tool was used to create 4 Pareto optimal plans.

Source: Medical Dosimetry - July 24, 2023 Category: Radiology Authors: Tsegawbizu Gebru, Kirk Luca, Jonathan Wolf, Oluwatosin Kayode, Xiaofeng Yang, Justin Roper, Jiahan Zhang Tags: Research Article Source Type: research