Obesity-induced dysregulation of skin-resident PPAR γ+ Treg cells promotes IL-17A-mediated psoriatic inflammation

Obesity is a major risk factor for inflammatory skin diseases, in particular psoriasis. Sivasami et  al. demonstrate that diet-induced obesity dysregulates a distinct subset of PPARγ+ Tregs in the skin via fatty-acid-induced lipotoxicity, which results in loss of control over IL-17A+ γδ T cell-mediated inflammation and exacerbated psoriasis.

Source: Immunity - July 20, 2023 Category: Allergy & Immunology Authors: Pulavendran Sivasami, Cody Elkins, Pamela P. Diaz-Saldana, Kyndal Goss, Amy Peng, Michael Hamersky, Jennifer Bae, Miaoer Xu, Brian P. Pollack, Edwin M. Horwitz, Christopher D. Scharer, Lindsey Seldin, Chaoran Li Tags: Article Source Type: research