The Role of NF- κB, PPAR-α, and PPAR-γ in Older Adults with Metabolic Syndrome
Horm Metab Res DOI: 10.1055/a-2109-1958The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood
yet, and chronic low-grade inflammation is thought to be associated with the
development of complications related to MetS. We aimed to investigate the role
of Nuclear factor Kappa B ( NF-κB ), Peroxisome Proliferator-Activated
Receptor- α and γ (PPAR-α, and PPAR-γ) which are
the main markers of inflammation in older adults with MetS. A total of 269
patients aged≥18, 188 patients with MetS who met the diagnostic criteria
of the International Diabetes Federation, and 81 controls who applied to
geriatrics and general internal medicine outpatient clinics for various reasons
were included in the study. Patients were separated into four groups: young with
MetS (< 60, n=76), elderly with MetS (≥60,
n=96), young control (< 60, n=31), elderly
controls (≥60, n=38). Carotid intima-media thickness (CIMT) and
NF-κB , PPAR-α, and PPAR-γ plasma levels were measured
in all of the participants. Age and sex distribution were similar between MetS
and control groups. C-reactive protein (CRP), NF-κB levels
(p=0.001) and CIMT (p<0,001) of MetS group were significantly
higher than in the control groups. On the other hand, the PPAR-γ
(p=0.008) and PPAR-α (p=0.003) levels were ...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Demirda ğ, Filiz Yavuzer, Serap Cengiz, Mahir Yavuzer, Hakan Kara, Zehra Ayvac ı, Adnan Avc ı, Suna Y ürüyen, Mehmet Uzun, Hafize Alt ıparmak, Mehmet Rıza D öventaş, Alper Erdin çler, Deniz Suna Tags: Original Article: Endocrine Research Source Type: research
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