The SCOUT study finally arrives

This study started recruiting in 2012 from two children’s hospital in Philadelphia and Pittsburgh and it took 7 years to recruit. Congratulations to the researchers. It illustrates, that to deliver a rigourous well managed, randomised controlled trial in children with a common clinical problem, it takes time and commitment. Zaoutis T et al (JAMA Pediatr doi:10.1001/jamapediatrics.2023.1979) have tackled the topic of antibiotic treatment for uncomplicated urinary tract infection (UTI) in children. How long should we treat for? They have compared the efficacy of standard-course (10 days) and short-course therapy (5 days) for children with UTI. Thus the ‘The Short Course Therapy for Urinary Tract Infections (SCOUT) trial which is a noninferiority clinical trial. There were 664 children aged 2 months to 10 years (median age 4 years) with UTI exhibiting clinical improvement after 5 days of antimicrobials were the study group. They then went on to have a further 5 days of...
Source: Archives of Disease in Childhood - Category: Pediatrics Tags: Miscellanea Source Type: research