Atypical antipsychotics attenuate MK801-induced social withdrawal and hyperlocomotion in the RHA rat model of schizophrenia-relevant features

ConclusionsThese results seem to be in line with previous studies with the NMDAR-antagonist model and add face (MK801-induced social withdrawal and hyperactivity) and predictive (attenuation of MK801-induced effects by atypical antipsychotics) validity to the RHA rat strain as a model of schizophrenia-relevant features.

http://link.springer.com/10.1007/s00213-023-06411-w

Source: Psychopharmacology - July 13, 2023 Category: Psychiatry Source Type: research