The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression

Biol Chem. 2023 Jul 13. doi: 10.1515/hsz-2023-0130. Online ahead of print.ABSTRACTCell viability largely depends on the surveillance of mRNA export and translation. Upon pre-mRNA processing and nuclear quality control, mature mRNAs are exported into the cytoplasm via Mex67-Mtr2 attachment. At the cytoplasmic site of the nuclear pore complex, the export receptor is displaced by the action of the DEAD-box RNA helicase Dbp5. Subsequent quality control of the open reading frame requires translation. Our studies suggest an involvement of Dbp5 in cytoplasmic no-go-and non-stop decay. Most importantly, we have also identified a key function for Dbp5 in translation termination, which identifies this helicase as a master regulator of mRNA expression.PMID:37436777 | DOI:10.1515/hsz-2023-0130

Source: Biological Chemistry - July 12, 2023 Category: Chemistry Authors: Luisa Querl Heike Krebber Source Type: research