Sex-Dependent Differences in Cholestasis

Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are cholestatic liver diseases that have significant clinical impact with debilitating symptoms and mortality. PBC is predominantly seen in perimenopausal and postmenopausal women; men who are diagnosed with PBC have worse clinical outcomes and all-cause mortality. In contrast, 60% to 70% of patients with PSC are men; the data indicate that female sex may be an independent factor against PSC-related complications. These findings suggest a sex-dependent biological basis for these differences.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research