Transcriptional derepression of CHD4/NuRD-regulated genes in the muscle of patients with dermatomyositis and anti-Mi2 autoantibodies

Conclusions
Based on these findings, we hypothesise that anti-Mi2 autoantibodies could exert a pathogenic effect by entering damaged myofibres, inhibiting the CHD4/NuRD complex, and subsequently derepressing the unique set of genes defined in this study.

Source: Annals of the Rheumatic Diseases - July 13, 2023 Category: Rheumatology Authors: Pinal-Fernandez, I., Milisenda, J. C., Pak, K., Munoz-Braceras, S., Casal-Dominguez, M., Torres-Ruiz, J., Dell'Orso, S., Naz, F., Gutierrez-Cruz, G., Duque-Jaimez, Y., Matas-Garcia, A., Padrosa, J., Garcia-Garcia, F. J., Guitart-Mampel, M., Garrabou, G., Tags: ARD, Myositis Source Type: research