Molecules, Vol. 28, Pages 5368: Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm
Molecules, Vol. 28, Pages 5368: Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm
Molecules doi: 10.3390/molecules28145368
Authors:
Jinghong Shi
Yucheng Wang
Wei He
Ziyue Ye
Mengli Liu
Zheng Zhao
Jacky Wing Yip Lam
Pengfei Zhang
Ryan Tsz Kin Kwok
Ben Zhong Tang
Biofilm-associated infections exert more severe and harmful attacks on human health since they can accelerate the generation and development of the antibiotic resistance of the embedded bacteria. Anti-biofilm materials and techniques that can eliminate biofilms effectively are in urgent demand. Therefore, we designed a type I photosensitizer (TTTDM) with an aggregation-induced emission (AIE) property and used F-127 to encapsulate the TTTDM into nanoparticles (F-127 AIE NPs). The NPs exhibit highly efficient ROS generation by enhancing intramolecular D–A interaction and confining molecular non-radiative transitions. Furthermore, the NPs can sufficiently penetrate the biofilm matrix and then detect and eliminate mature bacterial biofilms upon white light irradiation. This strategy holds great promise for the rapid detection and eradication of bacterial biofilms.
Source: Molecules - Category: Chemistry Authors: Jinghong Shi Yucheng Wang Wei He Ziyue Ye Mengli Liu Zheng Zhao Jacky Wing Yip Lam Pengfei Zhang Ryan Tsz Kin Kwok Ben Zhong Tang Tags: Article Source Type: research