Population pharmacokinetics of vancomycin in patients with diabetic foot infection: a comparison of five models

ConclusionsVancomycin PK parameters, particularly individualized Vd, may not be predictable by population nomograms in patients with DFI and stable renal function. Moreover, the weak correlation between AUC24 values and trough concentrations underlines the starting practice of vancomycin AUC24-based monitoring and dosing in the clinical setting.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research