The expression of parthanatos markers and miR-7 mimic protects photoreceptors from parthanatos by repressing α-synuclein in retinal detachment

Retinal detachment refers to the separation between the neuroepithelium and the pigment epithelium layer. It is an important disease leading to irreversible vision damage worldwide, in which photoreceptor cell death plays a major role. Alpha-synuclein ( α-syn) is reportedly involved in numerous mechanisms of neurodegenerative diseases, but the association with photoreceptor damage in retinal detachment has not been studied. In this research, elevated transcription levels of α-syn and parthanatos proteins were discovered in the vitreous of patient s with retinal detachment.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research