Role of the DOMINO diet application for managing IBS in primary care and beyond

We thank Rej et al for their interest in our DOMINO trial paper.1 2 In their letter, they point out that while the DOMINO application yields a statistically significant gain in responder rate over traditional medical therapy with otilonium bromide, the numerical difference is limited, as it amounts to only 10% at weeks 4 and 8. We want to point out that these margins are in the order of magnitude of the gain in response rate over placebo in recent trials with novel drugs for the treatment of Irritable Bowel Syndrome (IBS) that have seen regulatory approval.3–6 In addition, the attractiveness of the dietary approach in our view is not predominantly determined by superior efficacy compared with medical therapy. As the patient, through the diet smartphone application, achieves the ability to control symptoms using relatively simple dietary...

Source: Gut - July 6, 2023 Category: Gastroenterology Authors: Tack, J., Van den Houte, K., Carbone, F. Tags: Gut PostScript Source Type: research