Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells

Since the accomplishment of Human Genome Project in 2002 and with the advancement of various high-throughput research strategies, characterization of previously ill-defined genes or discovery of novel functions of known genes has been accelerated, which in turn facilitates the discovery of the pathogenesis of or effective therapies for diseases. In the past decade, we investigated the potential role of a less-cared gene, matrix remodeling associated 7 (MXRA7), in different pathophysiological processes including leukemia.

Source: Experimental Hematology - July 5, 2023 Category: Hematology Authors: Zhenjiang Sun, Dandan Lin, Ying Shen, Kunpeng Ma, Benfang Wang, Hong Liu, Suning Chen, Depei Wu, Yiqiang Wang Tags: Article Source Type: research