Manadodioxans A−E: polyketide endoperoxides from the marine sponge Plakortis bergquistae

Abstract Five new polyketide endoperoxides, manadodioxans A−E, were isolated from the marine sponge Plakortis bergquistae. Manadodioxan E showed antimicrobial activity against Escherichia coli at 10 μg/disk, while its oxo congener, manadodioxan D, was inactive.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research