The multifaceted nature of peroxiredoxins in chemical biology

Curr Opin Chem Biol. 2023 Jun 27;76:102355. doi: 10.1016/j.cbpa.2023.102355. Online ahead of print.ABSTRACTPeroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H2O2 detoxifiers, and more recently as H2O2 sensors, intermediates in redox-signaling pathways, metabolism modulators, and chaperones. The multifaceted nature of Prx is not only dependent on their peroxidase activity but also strongly associated with specific protein-protein interactions that are being identified, and where the Prx oligomerization dynamics plays a role. Their oxidation by a peroxide substrate forms a sulfenic acid that opens a route to channel the redox signal to diverse protein targets. Recent research underscores the importance of different Prx isoforms in the cellular processes behind disease development with potential therapeutic applications.PMID:37385138 | DOI:10.1016/j.cbpa.2023.102355
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Source Type: research