Ongoing HIV-1 evolution and reservoir reseeding in two elite controllers with genetically diverse peripheral proviral quasispecies

CONCLUSIONS: These findings support that the high intra-host HIV-1 diversity of some EC resulted from long-term persistence of archival proviruses combined with the continuous reservoir's reseeding and low, but measurable, viral evolution despite undetectable viremia.PMID:37283423 | PMC:PMC10292822 | DOI:10.1590/0074-02760230066

Source: Memorias do Instituto Oswaldo Cruz - June 7, 2023 Category: Infectious Diseases Authors: Suwellen Sardinha Dias de Azevedo Fernanda Heloise C ôrtes Larissa M Villela Brenda Hoagland Beatriz Grinsztejn Valdilea Gon çalvez Veloso Mariza G Morgado Gonzalo Bello Source Type: research