Two are not enough: synthetic strategies and applications of unnatural base pairs

Biol Chem. 2023 Jun 26. doi: 10.1515/hsz-2023-0169. Online ahead of print.ABSTRACTNucleic acid chemistry is a rapidly evolving field, and the need for novel nucleotide modifications and artificial nucleotide building blocks for diagnostic and therapeutic use, material science or for studying cellular processes continues unabated. This review focusses on the development and application of unnatural base pairs as part of an expanded genetic alphabet. Not only recent developments in "nature-like" artificial base pairs are presented, but also current synthetic methods to get access to C-glycosidic nucleotides. Wide-ranging viability in synthesis is a prerequisite for the successful use of unnatural base pairs in a broader spectrum and will be discussed.PMID:37354104 | DOI:10.1515/hsz-2023-0169

Source: Biological Chemistry - June 24, 2023 Category: Chemistry Authors: Robert D örrenhaus Philip K Wagner Stephanie Kath-Schorr Source Type: research