A triple dose of optimism: an initial foray into triplet therapy in metastatic renal cell carcinoma

Nature Reviews Clinical Oncology, Published online: 23 June 2023; doi:10.1038/s41571-023-00795-6COSMIC-313 combines all of the approved drugs against actionable targets in renal cell carcinoma into one triplet regimen. Although this approach has greater clinical efficacy than one of the standard-of-care doublet therapies, toxicities can limit adequate drug administration and, thus, we argue that this regimen should not yet be adopted. We also discuss ongoing investigations of other triplet regimens.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research