Chimeric Antigen Receptor T-Cell Therapy in Aggressive B-Cell Lymphoma

Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary therapy increasingly used in the treatment of non-Hodgkin B-cell lymphoma. This review focuses on the use of CAR T-cell therapy in aggressive B-cell lymphoma including clinical indications, known short- and long-term toxicity, mechanisms of CAR T-cell efficacy and tumor resistance, and future directions in the treatment of aggressive lymphoma with CAR T-cell therapy.

Source: Hematology/Oncology Clinics of North America - June 20, 2023 Category: Cancer & Oncology Authors: Mark P. Hamilton, David B. Miklos Source Type: research