Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells

Most adult hematopoietic stem cells (HSCs) maintain a quiescent state in physiological conditions [1, 2], and quiescence is closely related to HSC function [3]. Energy metabolism plays a crucial role in maintaining HSC quiescence [4, 5], shielding HSCs from accumulation of DNA damage and diminishment of repopulation capacity. HSCs are more metabolically inactive than progenitors, exemplified by low adenosine-triphosphate (ATP) production, low protein synthesis rate [6], low mTORC activity accompanied by high nuclear FOXO levels [7, 8], high autophagic activity upon metabolic stress [9-11], dependence on fatty acid oxidation as a fuel substrate [12], and low ROS production [13, 14].

Source: Experimental Hematology - June 18, 2023 Category: Hematology Authors: Kohei Shiroshita, Hiroshi Kobayashi, Shintaro Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinpei Tamaki, Miho Haraguchi, Masamichi Yamamoto, Ayako Nakamura-Ishizu, Shinichiro Okamoto, Keisuke Kataoka, Keiyo Takubo Tags: Article Source Type: research