Evaluation of Sensitive Urine DNA-based PENK Methylation Test for Detecting Bladder Cancer in Patients with Hematuria

This study introduces and validates a highly sensitive urine-based DNA methylation test. The test improves sensitivity in detecting PENK methylation in urine DNA using Linear Target Enrichment (LTE) followed by quantitative methylation-specific PCR (qMSP) (mePENK-LTE/qMSP).

Source: Journal of Molecular Diagnostics - June 14, 2023 Category: Pathology Authors: Tae Jeong Oh, Ji Yong Lee, Yangyei Seo, Min A. Woo, Jae Sung Lim, Yong Gil Na, Ki Hak Song, Bo-Ram Bang, Justin Junguek Lee, Ju Hyun Shin, Sungwhan An Tags: Regular Article Source Type: research