Risk Factors for Preoperative Cerebral Infarction in Infants with Moyamoya Disease

AbstractThere have been few reports on the risk factors for preoperative cerebral infarction in childhood moyamoya disease (MMD) in infants under 4 years. The aim of this retrospective study is to identify clinical and radiological risk factors for preoperative cerebral infarction in infants under 4 years old with MMD, and the optimal timing for EDAS was also considered. We retrospectively analyzed the risk factors for preoperative cerebral infarction, confirmed by magnetic resonance angiography (MRA), in pediatric patients aged ˂4 years who underwent encephaloduroarteriosynangiosis between April 2005 and July 2022. The clinical and radiological outcomes were determined by two independent reviewers. In addition, potential risk factors for preoperative cerebral infarction, including infarctions at diagnosis and while awaiti ng surgery, were analyzed using a univariate model and multivariate logistic regression to identify independent predictors of preoperative cerebral infarction. A total of 160 hemispheres from 83 patients aged<4 years with MMD were included in this study. The mean age of all surgical hemispheres at diagnosis was 2.17 ±0.831 years (range 0.380–3.81 years). In the multivariate logistic regression model, we included all variables withP<0.1 in the univariate analysis. The multivariate logistic regression analysis indicated that preoperative MRA grade (odds ratio [OR], 2.05 [95% confidence interval [CI], 1.3 –3.25],P=0. 002), and age at diagnosis (OR,...
Source: Translational Stroke Research - Category: Neurology Source Type: research