Get into the groove! The influence of TAPBPR on cargo selection

Curr Opin Immunol. 2023 Jun 7;83:102346. doi: 10.1016/j.coi.2023.102346. Online ahead of print.ABSTRACTSince the discovery of Transporter associated with antigen processing-binding protein-related (TAPBPR) over two decades ago, extensive studies have explored its function in the context of the major histocompatibility complex class-I (MHC-I) antigen processing and presentation pathway. As a chaperone and peptide editor, TAPBPR was recently revealed to have overlapping structural features when resolved with peptide-receptive MHC-I molecules compared with the two newly solved tapasin:MHC-I structures. Despite this, the two chaperones seem to have a unique criteria for loading high-affinity peptides on MHC-I molecules. Yet, the mechanism of action of how TAPBPR creates its distinct filter in cargo selection for peptide-receptive MHC-I molecules continues to be a subject of debate.PMID:37295041 | DOI:10.1016/j.coi.2023.102346

Source: Current Opinion in Immunology - June 9, 2023 Category: Allergy & Immunology Authors: Reem Satti Jack L Morley Louise H Boyle Source Type: research