Lignans With α-Glucosidase Inhibitory Activity from Codonopsis pilosula

The chemical constituents of Codonopsis pilosula (Franch.) Nannf. were isolated and purified by column chromatography. Two lignans were obtained from an ethanol extract of the roots of C. pilosula, including one new lignan [diethyl lithospermate (1)] and one new natural product [diethyl lithospermate B (2)]. The structures of these compounds were identified using spectroscopic data. Theα-glucosidase inhibitory effects of all compounds were measured by thep-nitrophenyl-α-D-glucopyranoside method. Compounds1 and2 exhibited good inhibitory activity with half-maximal inhibitor concentrations of 0.79 ± 0.03 μM and 0.16 ± 0.02 μM, respectively.

Source: Chemistry of Natural Compounds - June 8, 2023 Category: Chemistry Source Type: research