Development and physicochemical characterization of a biodegradable microspheres formulation loaded with samarium ‐153 and doxorubicin for chemo‐radioembolization of liver tumours

In conclusion, a novel biodegradable microspheres formulation loaded with chemotherapeutic drug (Dox) and radioactive agent (153Sm) was successfully developed in this study. The formulation fulfilled all the desired physicochemical properties of a chemo-radioembolic agent and achieved better in vitro cytotoxicity on HepG2 cells. Further investigations are needed to evaluate the biosafety, radiation dosimetry, and synergetic anticancer properties of the formulation.

Source: Journal of Labelled Compounds and Radiopharmaceuticals - June 8, 2023 Category: Biochemistry Authors: Asseel Hisham Alregib, Hun Yee Tan, Yin How Wong, Azahari Kasbollah, Eng Hwa Wong, Basri Johan Jeet Abdullah, Alan Christopher Perkins, Chai Hong Yeong Tags: RESEARCH ARTICLE Source Type: research