The effects of novel macrocyclic chelates on the targeting properties of the 68Ga-labeled Gastrin releasing peptide receptor antagonist RM2

ConclusionsThe conditions for complexation of DATA5m-RM2 and AAZTA5-RM2 with gallium-68 are milder, faster and require less amount of precursors than DOTA-RM2. Chelators had an evident influence on the pharmacokinetics and targeting properties of68Ga-X-RM2 derivatives. Positively charged68Ga-DATA5m-RM2 provided a high tumor uptake, high image contrast and good capability of targeting GRPr.

http://link.springer.com/10.1186/s13550-023-01005-1

Source: EJNMMI Research - June 7, 2023 Category: Radiology Source Type: research